Methemoglobin is a form of hemoglobin that contains the iron Fe3. Madison Cawein began hearing rumors about the blue people when he went to work at the University of Kentucky's Lexington medical clinic in 1960. Benjamin’s father remembered that the last blue Fugate before Benjamin had been his grandmother, Luna, who was a dark blue her whole life. What if these Blue people, or even the Melungeons of eastern Kentucky (who by the way, migrated from the Carolinas in their own lore) could be the lost piece of this Atlantean Colonial system. The Fugate family of Kentucky has been known for their blue skin color for generations. Not knowing this fact, the blue people of Kentucky were shamed by their uniqueness & misled by a Country Doctor. [5], It has been speculated that some other Americans who inherited methemoglobinemia may also have had Fugate ancestors, but searches for direct links have so far proved inconclusive.[6]. See more ideas about kentucky, people, medical oddities. It is a rare condition that arises when the methemoglobin levels in your blood rise above 1 percent. Fast forward to the seventies and Benjamin Stacy has just been born. Are there really blue skinned people living in Kentucky? As time passed, descendants of the family moved out of the area, and new populations moved in, which allowed the Fugates to meet and marry people who did not share their genes at all. Those who are otherwise healthy with levels under 15% may exhibit minor symptoms or none at all. Named after an early settler. [2][6] He found that a report from 1960 by a public health doctor, E. M. Scott, who published in the Journal of Clinical Investigation his research on the phenomenon among native Alaskans, based on the theory that a deficiency of the enzyme diaphorase is the cause of the oxygen deficiency in the red blood cells, causing the blood to appear brown, which in turn made the skin of those affected appear blue. "I'm a hematologist, so something like that perks up my ears," Cawein says, sipping on whiskey sours and letting his mind slip back to the summer he spent "tromping around the hills looking for blue people." Which suggests that the Blue people of Kentucky are not just an urban legend. Methemoglobin levels over 50% may result in seizures, coma, and death. Not myth or legend; The Blue People of Kentucky were an isolated enclave of Appalachian people who lived with an embarrassing skin discoloration until a young hematologist took notice and found a solution. The color of their skin was so shocking for normal people to see, that they chose to stay hidden away from the rest of society in their small community. The Fugates and their descendants were forced to show the world their history of inter-marriage with their blue skin. When the “Pandemic of 2020” hit I was reading “The Book Woman of Troublesome Creek.” The book is a story about a young woman who lived in the Appalachian Mountains of Eastern Kentucky during the 1930s. I recently took a genetics course this past spring semester and learnt a lot about genetic mutations which can be sex-linked, linked or un-linked. Our new student and parent forum, at ExpertHub.PrepScholar.com, allow you to interact with your peers and the PrepScholar staff. Usually, when we think blue people in Kentucky, the first thing that comes to mind is University of Kentucky Wildcat fans… as they are known to dress in and paint their faces blue to show team spirit. blue troublesome creek was white to connect it was blue people of kentucky. Samuel Haddix, a native… In the early 1960’s, two blue descendants of the family, Rachel and Patrick Ritchie, met Doctor Madison Cawein III. Named after an early settler. March 7, … When he was born, Benjamin was so blue he was almost purple, which caused panic at the hospital. The Legend Of Kentucky’s Blue People Is Truly Bizarre People come in all types of colors and shades of colors, but they are normally red, brown, yellows, browns, pinks, black, and white. Jan 25, 2014 - Explore Janice Jordan's board "Blue People of Kentucky", followed by 192 people on Pinterest. You can also explore how animals are biologically related to each other in Homologous and Analogous Structures: What's the Difference? The Fugates’ son, Zacariah, married Elizabeth’s sister/his aunt. The last known member of the Huntsville subgroup to be born with blue skin was Benjamin Stacy in 1975. The Fugates, a family that lived in the hills of Kentucky, commonly known as the "Blue Fugates"[1] or the "Blue People of Kentucky", are notable for having been carriers of a genetic trait that led to the blood disorder methemoglobinemia, which causes the appearance of blue-tinged skin. In the late 1950s, a hematologist named Martin Cawein from the University of Kentucky was fascinated by the stories of the blue Fugate family. "Blue-skinned family baffled science for 150 years", article on the Fugates of Appalachia, an extended family of blue-skinned people, "Fugates of Kentucky: Skin Bluer than Lake Louise", "Blue People Look for Genetic Connection to Kentucky Fugates", https://en.wikipedia.org/w/index.php?title=Blue_Fugates&oldid=988865350, Creative Commons Attribution-ShareAlike License, This page was last edited on 15 November 2020, at 18:44. The isolation made this difficult, and created a strangely perfect environment for the hereditary disorder to continue. The Blue People of Kentucky and the Pack Horse Library Project are both fascinating historical realities that are barely understood today. His passion and desire to become popular in the books of history made him unravel the mystery of the Blue people in Kentucky. In the 1960s, a hematologist in Lexington, Kentucky embarked on a bizarre quest. Some use of antibiotics can lead to methemoglobinemia, as can use of local anesthetics and the ingestions of nitrates. Unknown to the couple at the time they both carried a … A man named Paul Karason famously turned blue after getting argyria, as a result of drinking colloidal silver for alleged health benefits. by Cathy Trost ©Science 82, November, 1982. As the story goes, Martin Fugate, a French orphan, settled on the banks of eastern Kentucky's Troublesome Creek around 1820 to claim a land grant. Cawein ran tests, and discovered that the levels of methemoglobin in the blood were extremely high. Samuel Haddix, a native… Very few people knew they even existed, until today. The most detailed account, "Blue People of Troublesome Creek," was published in 1982 by the University of Indiana's Cathy Trost. The Fugates, a family that lived in the hills of Kentucky, commonly known as the "Blue Fugates" or the "Blue People of Kentucky", are notable for having been carriers of a genetic trait that led to the blood disorder methemoglobinemia, which causes the appearance of blue-tinged skin. The doctor hiked through the Appalachian hills, on a mission to find the famous blue people of Kentucky. Check out this post about cell theory and why it's important and a discussion of enzymes and what they do. Carrie holds a Bachelors in Writing, Literature, and Publishing from Emerson College, and is currently pursuing an MFA. Oyata Bulaya says: May 17, 2018 at 1:03 am. Samuel Haddix, a native of Virginia. As a result of this weird disorder, they decided to isolate themselves from the community. In an unusual story that involves both genetics and geography, an entire family from isolated Appalachia was tinged blue. Ask questions; get answers. Green cannot definitively trace his lineage back to the Fugates, but suspects he inherited the disorder from his father, whom he never met. Normal methemoglobin levels are less than 1%. Get the latest articles and test prep tips! The disorder is extremely rare. Blood is also likely to be a chocolate brown color instead of bright red in patients with methemoglobinemia. Kept to have plenty of troublesome worksheet alaskans scott speculated these were reported to achieve a situation that turned his aunt bessie fugate, learn more travelers to understand. With two carrier parents, a child would have a ¼ chance of being born with methemoglobinemia, a 2/4 chance of being an unaffected carrier, and a ¼ chance of not inheriting the gene at all. Stemming from French immigrant Martin Fugate, who moved to Kentucky in 1820, the blue people were to become legends in their own right. There were no roads, and the railroad would not reach the area until 1910. The Fugates probably had a deficiency in the enzyme called cytochrome-b5 methemoglobin reductase, which is responsible for recessive congenital methemoglobinemia. Jan 25, 2014 - Explore Janice Jordan's board "Blue People of Kentucky", followed by 192 people on Pinterest. The Fugates, a family that lived in the hills of Kentucky, commonly known as the "Blue Fugates" or the "Blue People of Kentucky", are notable for having been carriers of a genetic trait that led to the blood disorder methemoglobinemia, which causes the appearance of blue-tinged skin. He finally found a couplePatrick and Rachel Ritchiewho was willing to participate in his study. The 5 Strategies You Must Be Using to Improve 4+ ACT Points, How to Get a Perfect 36 ACT, by a Perfect Scorer. Neighbors laughed at the family’s blue coloring and most avoided the Fugates. . The Blue People of Kentucky are still discussed, but less is known about. People with severe methemoglobinemia (methemoglobin level above 50%) may exhibit ... a family that lived in the hills of Kentucky, had the hereditary form. Our story starts near the town of Hazard, Kentucky where Martin Fugate and Elizabeth Smith settled down. Read the following article on the Blue Family in Kentucky. She has blue skin. Telegram. Both Zacariah and his wife were non-blue skinned carriers of the gene, and then Zacariah's children went on to marry his younger siblings and their children. Cussy is a nineteen year old and she is the last living female of the rare Blue People ancestry. Ask below and we'll reply! Blue People Genealogy. By SUSAN DONALDSON JAMES. The Fugates also showed the importance of access to medicine and medical information. 017 | Blue People of Kentucky from Southern Oddities on Podchaser, aired Thursday, 14th January 2021. Mar 14, 2017 - Explore Carol Kline's board "Blue Fugates of Kentucky", followed by 227 people on Pinterest. Haddix, Kentucky.. is an unincorporated community and coal town in Breathitt County, Kentucky. They settled in Troublesome Creek, Kentucky. Patients then take pills for as long as they wish to continue being not-blue. It was a military doctor and hematologist by the name Madison Cawein, who figured out what was ‘wrong’ with the blue people and treated them. Unbeknownst to the couple, they were coincidentally both carriers of a recessive gene (met-H) that caused methemoglobinemia, which can tint the skin of sufferers blue. 00:10:34 - Haddix, Kentucky.. is an unincorporated community and coal town in Breathitt County, Kentucky. Exposure to the oxidizing drugs can overwhelm the system, and convert hemoglobin into methemoglobin. As the Fugates had children with people outside of the isolated Kentucky mountains that they’d originally settled, the likelihood of inheriting met-H decreased. Way back in 1820, a French immigrant named Martin Fugate settled in the mining country of eastern Kentucky in a small town called Troublesome Creek. The Blue People of Kentucky and the Pack Horse Library Project are both fascinating historical realities that are barely understood today. Named after an early settler. Source – The Mind Unleashed Since it is a recessive gene, the likelihood for inheriting it becomes less likely with each generation that marries outside of the Fugate line. Image: via NClark Illustration of Martin Fugate and his family. Sit back, relax, and read the amazing but true genetic tale of the Blue People of Kentucky. There is more evidence to this argument but I don't want to waste your time. He began hearing rumors about these blue people when he went to work at the University of Kentucky’s Lexington medical clinic in 1960.… (John Vibes) The Fugates, a blue-skinned family from the hills of Kentucky has attracted and baffled scientists for generations, although their condition has now been explained as being caused by the disease Methemoglobinemia, which can make a person’s skin blue. Haddix is located near the confluen… Deep in the woods of Kentucky, a fiercely private family gave birth to blue-skinned children since the 1800s. in the right direction in my search for the mysterious Blue People of the Cherokee Legends. Methylene blue restores normal iron levels in the blood by providing an artificial election receptor, which allows the NADH enzyme to work beyond its normal capacity. This is sometimes called “blue baby syndrome” and those who have private water systems are at higher risk of nitrate exposure and therefore higher risk of the syndrome. Old color photographs of the family clearly show about half of the members to have a distinct cobalt blue skin color, while the other have regular white skin color. Doctor Ayalew Tefferi of the Mayo Clinic told ABC news in 2013 that “You almost never see it.” Kerry Green, an Oklahoma native, has a severe version of the disease that affects his health, and his body has trouble carrying oxygen to his organs. They rushed him by ambulance to… The doctors were astonished by the color of Benjy’s skin. They are known as the "Blue Fugates". For nearly two centuries, the Fugate family of Kentucky passed their unique characteristic of blue skin from one generation to the next. Most stories about the blue people of Kentucky include an eerie, compelling drawing of a family, with the stark faces of 5 of the 9 members a striking bluish-gray, due to an inherited disease. Sit back, relax, and read the amazing but true genetic tale of the Blue People of Kentucky. Martin and Elizabeth had seven children, four of whom had blue skin. What ACT target score should you be aiming for? … He married a red-haired American named Elizabeth Smith with a very pale complexion. Cussy is a pack horse librarian and she delivers books to people that live in the mountains of Kentucky. 00:10:34 - Haddix, Kentucky.. is an unincorporated community and coal town in Breathitt County, Kentucky. Another woman named Jennifer L. Adams Horsley of Indiana believed her mother-in-law had the condition as well. She worked in book publishing for several years, and believes that books can open up new worlds. by Cathy Trost ©Science 82, November, 1982. Related Love Makes Us More Intelligent, According to Neuroscience. In a diverse gene pool, a recessive trait like this one would have died out quickly, or only been a rare occurrence. What if these Blue people, or even the Melungeons of eastern Kentucky (who by the way, migrated from the Carolinas in their own lore) could be the lost piece of this Atlantean Colonial system. Most stories also borrow heavily from a terrific article by Cathy Frost from Science 82, a long-gone magazine that I quite liked. As ABC details, Dr. Madison Cawein III set out to find a group of blue people.At first blush, this mission smacks pure lunacy, or even purer cocaine.Did this guy get high and convince himself he was Gargamel searching for Smurfs?Shockingly not. Many Fugates were in good health despite having methemoglobinemia, and some reportedly lived into their 90’s. The short answer is no, but a more accurate one would be ‘no more’. Meanwhile, much earlier in 1960, the stories of the blue people of Troublesome Creek caught the attention of a young haematologist Dr. Madison Cawein. In the 1800s a family of blue-skinned people fascinated and, as we might imagine given the times, horrified many people in the state of Kentucky. Story Behind “The Blue People in Kentucky” – Blue Fugates Family. Many people wondered if there was someone that heard about these people and help them and actually there was. The Blue People of Kentucky, also known as the Blue Fugates, have long been of scientific interest. As the story goes, Martin Fugate, a French orphan, settled on the banks of eastern Kentucky's Troublesome Creek around 1820 to claim a land grant. This is especially true of the ‘Blue People of Kentucky’. The Blue Fugates, sometimes known as the Huntsville subgroup,  were well known in the area, and their genetic disorder went unidentified until the mid twentieth century, when the amount of affected people had greatly decreased. Twitter. Also, be sure to note the family lineage that is presented to you in the text, you will need it for part of your assignment. Although the blue people of Kentucky are a real phenomenon that has been well documented and written about in all manner of publications from science journals to mass-market magazines, I really don't want you goofballs loading your cameras and going on a gawking spree, bothering innocent people. Original source unknown, via ABC News The Blue Fugates are shown in this colorized black and white photo. Ngozika. As ABC details, Dr. Madison Cawein III set out to find a group of blue people.At first blush, this mission smacks pure lunacy, or even purer cocaine.Did this guy get high and convince himself he was Gargamel searching for Smurfs?Shockingly not. hbspt.cta.load(360031, '4efd5fbd-40d7-4b12-8674-6c4f312edd05', {}); Have any questions about this article or other topics? This book explores the life of Cussy Carter, the last living female of the rare Blue People ancestry and is based on true life. [7] He eventually published his research in the Archives of Internal Medicine in 1964. This novel is a love letter to books. The are… Cawein had just started work at the University of Kentucky’s Lexington medical clinic. They became known locally as the Blue Fugates. Martin and Elizabeth had seven children, four of whom had blue skin. Share. Scientists were quite intrigued as to the cause of the blue skin (cyanosis) in the Fugate family. [8], Benjamin Stacy, born in 1975, is the last known descendant of the Fugates to have been born exhibiting the characteristic blue color of the disorder, though he quickly lost his blue skin tone, exhibiting only blue tinges on his lips and fingertips if he was cold, or agitated. They settled in Troublesome Creek, Kentucky. In the 1960s, a hematologist in Lexington, Kentucky embarked on a bizarre quest. One of the most recent descendents that was born blue was Benjamin “Benjy” Stacy. Martin Fugate, a French orphan, married a woman named Elizabeth around 1820. For a hundred and fifty years, locals in the area of Hazard, Kentucky were stumped by a group of people. Shame, psychological trauma, and discrimination resulted in that the Blue People of Kentucky isolated themselves from the rest of society. Since neither parent had symptoms of methemoglobinemia, they were shocked and confused, and no one could offer an explanation. This is wonderful, but it could facilitate transmission of the disease when carriers have children together. There are no known blue-skinned Fugates today. This is why the Fugate family was affected so frequently. Karason’s blue appearance and white beard drew comparisons to Papa Smurf, and brought renewed attention to the Fugate family though Karason’s ailment was unrelated. Yet Facebook groups have enabled the meeting of many people who have mutations in the same gene. The family was from upper Kentucky, and Horsley claimed her mother-in-law’s nails and lips were always blue, and got worse if she were cold, upset, or angry. Isolation and in-breeding passed on the disorder. It’s recommended that the Methylene blue is first injected slowly, and repeated if necessary. As time went on, fewer and fewer people with the condition were born and the blue skin condition disappeared altogether. Some reports say Martin was not blue but was a carrier of the methemoglobinemia gene. THE BLUE PEOPLE OF TROUBLESOME CREEK The story of an Appalachian malady, an inquisitive doctor, and a paradoxical cure. Be sure to jot down important information as to how these people turned blue. Here, he planned to start a family with his new bride, a red-haired, pale woman named Elizabeth Smith. Neighbors used to laugh at the family’s blue appearance. Usually, when we think blue people in Kentucky, the first thing that comes to mind is University of Kentucky Wildcat fans… as they are known to dress in and paint their faces blue to show team spirit. They are known as the "Blue Fugates". See more ideas about kentucky, blue, appalachia. All Blue Fugates were stigmatized due to their unusual appearance. In 2019, the novel The Book Woman of Troublesome Creek, by Kim Michele Richardson, described a fictional version of the Fugate family during the Great Depression. With two parents that were potentially carriers, or affected themselves, it increased the likelihood of having children who inherited the disorder or were unaffected carriers. The novel is securely rooted in a time and place — Depression-era rural Kentucky — and yet it still speaks to universal truths about the power of the written word, literacy and the free exchange of ideas. In the 1960s, a young hematologist named Madison Cawein traveled to the region with an aim to cure the blue people of their skin color. He determined that injections of methylene blue would be able to cure them (more later on why that worked). SAT® is a registered trademark of the College Entrance Examination BoardTM. Unfortunately, this meant that other families in nearby communities were less likely to marry into the Fugate family for fear that they would also have blue-skinned children. It’s not likely that this would be permanent, and is also unlikely to cause the "blue all over" look of the Fugates. The Blue people of Kentucky were segregated in the 1930s much the same as those who had anything but white skin. Again, they were unable to prove a connection to the Fugates. Life for the Blue people of Kentucky was not a dance on roses. Diagnosis and Treatment of the Blue Fugates of Kentucky. I enjoy historically based novels because I can see into a world different from my own. As a result, four of their seven children exhibited blue skin, and continued progenation within the very limited local gene pool ensured that many descendants of the Fugates were born with met-H.[3][4][5], Descendants with the gene continued to live in the areas around Troublesome Creek and Ball Creek into the 20th century, eventually coming to the attention of the nurse Ruth Pendergrass and the hematologist Madison Cawein III, who made a detailed study of their condition and ancestry. The Fugates and the met-H gene they passed for generations can teach us a valuable lesson about genetics and understanding disease. Then it converts from hemoglobin to methemoglobin. The Blue People Of Kentucky: For almost two centuries, the “blue skinned people of the Fugate family” lived in the areas of Troublesome Creek and Ball Creek in the hills of eastern Kentucky. Patrick and Rachel Ritchie, Fugate descendants, were cured by injections of methylene blue. Hemoglobin is the protein in red blood cells that is responsible for transporting oxygen throughout the body, and raised levels of methemoglobin happen when the mechanisms that defend against oxidative stress are overwhelmed by Fe3. Or if you can't get enough offbeat history, check out The History of the Hole Punch and The True Story of David Ghantt and the Loomis Wells Fargo Heist. The College Entrance Examination BoardTM does not endorse, nor is it affiliated in any way with the owner or any content of this site. Source – The Mind Unleashed Why Are They Blue? Since neither parent had symptoms of methemoglobinemia, they were shocked and confused, and no one could offer an explanation. Related Love Makes Us More Intelligent, According to Neuroscience. Benjamin lost his blue coloring within a few weeks. Blue People Look for Genetic Connection to Kentucky Fugates Rare genetic condition gives people blue skin color. Martin Fugate, a French orphan, married a woman named Elizabeth around 1820. [5], Cawein treated the family with methylene blue, which eased their symptoms and reduced the blue coloring of their skin. The color of their skin was so shocking for normal people to see, that they chose to stay hidden away from the rest of society in their small community. See more ideas about kentucky, people, medical oddities. Others might think of the Blue Man Group or even the Smurfs. Blue People of Kentucky, Appalachia (Blue People of Kentucky) Fugates: The genetic form of methemoglobinemia is caused by one of several genetic defects. Facebook . Looking for more information on how cells, enzymes, and genetics work? When a new baby was born it happened that the blue color faded soon after birth, but often adults had to face life-long suffering, being blue-skinned and different from all other human beings. When Benjy was born his skin was a dark blue. The answer is methemoglobinemia. Get Free Guides to Boost Your SAT/ACT Score, Homologous and Analogous Structures: What's the Difference. The Fugate Family Of Kentucky Has Had Blue Skin For Centuries — Here’s Why For nearly 200 years, the Fugate family of Kentucky remained largely sealed off from the outside world as they passed their blue skin from generation to generation. Blue people’s life wasn’t that easy. Met-H is a recessive gene that occurs due to an enzyme deficiency (NADH) which prohibits oxygen from traveling in the blood. The area was extremely rural and isolated in the nineteenth century. There is more evidence to this argument but I don't want to waste your time. A sad recent example is the Martin Fugate came to Troublesome Creek (near Hazard) from France in 1820 and… well… he happened to be blue. A Comprehensive Guide. Due to their isolation, the Fugates began inter-marrying, which led to a higher likelihood of passing along the met-H gene, and having blue-skinned children. People with methemoglobin levels above 10% may experience shortness of breath, headache, fatigue, dizziness, loss of consciousness, and cyanosis, the blue skin color that the Fugates were known for. He was born in a hospital near Hazard, Kentucky. Vitamin C has also been used to reduce cyanosis temporarily. He injected both patients with methylene blue, and nurse Ruth Pendergrass noted that they “changed color before her eyes.” Both patients continued to take methylene pills to make sure their blue color didn’t return. Cawein remembered that the two were embarrassed to be blue-skinned, since it had become associated in the area with inter-marriage. THE BLUE PEOPLE OF TROUBLESOME CREEK The story of an Appalachian malady, an inquisitive doctor, and a paradoxical cure. Reference: Adapted from an article in Science 82, November 1982 by Cathy Trost For more information on the Blue Fugates of Kentucky go to google.com and type in blue fugates The 5 Strategies You Must Be Using to Improve 160+ SAT Points, How to Get a Perfect 1600, by a Perfect Scorer, Free Complete Official SAT Practice Tests. Just my opinion.. Blue Rules! Deep in the woods of Kentucky, a fiercely private family gave birth to blue-skinned children since the 1800s. They eventually passed their unique characteristic from generation to generation, remaining largely isolated from the outside world. Unbeknownst to the couple, they were coincidentally both carriers of a recessive gene (met-H) that caused methemoglobinemia, which can tint the skin of sufferers blue. Blue People of Kentucky Why the Fugate Family Had Blue SkinA Frenchman arrived in Kentucky in 1820, bringing with him his strange blue skin. Richardson’s novel, which she began writing in 2016 and published in May, is a first-person narrative about a woman named Cussy Mary Carter, who has a rare genetic condition that makes her skin appear blue (based on the real-life blue-skinned people of Kentucky). The Blue People of Kentucky Scroll down to content. In 1960, he decided to move near Troublesome Creek in the hopes to meet one of them some day. The ailment, which was later revealed to be a symptom of methemoglobinemia, was contained mostly to descendants of the Fugate family of Troublesome Creek, and a related family in nearby Ball Creek. The ancestral line began with a French orphan, Martin Fugate, who settled in Eastern Kentucky. The year is 1936 and the setting takes place in the Appalachian Mountains into the woods of Troublesome Creek. Benjy is Martin Fugates great-great-great-great grandson. He made frequent trips to Hazard in the hope of finding some blue people. Shame, psychological trauma, and discrimination resulted in that the Blue People of Kentucky isolated themselves from the rest of society. Very few people knew they even existed, until […] With regard to the other blue people of Kentucky; following the opening up of rail tracks and motorable roads, they began to move away to other communities and inter-marry with people without the gene. Their ancestral line began six generations earlier with a French orphan, Martin Fugate, who settled in Eastern Kentucky. Old color photographs of the family clearly show about half of the members to have a distinct cobalt blue skin color, while the other have regular white skin color. WhatsApp. The True Story of David Ghantt and the Loomis Wells Fargo Heist. Because of their family and their prominence as Blue People of Kentucky, patients today, especially blue-syndrome babies, have the benefit of information about methemoglobinemia and options for cures and treatments. 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